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Since then … For example, Drosophila Sh mutants exhibit aberrant movements that are most pronounced under ether anesthesia, when the mutant flies’ legs shake (hence the name Shaker, which describes the mutant phenotype) [17–19]. The complex is the structural locus of a family of potassium channels as well as a number of functions relevant to the biology of the nervous system. Thank you for sharing this Genetics article. The molecular basis of three exemplary Sh alleles (ShKS133, ShE62 and Sh5) has been identified. The IA potassium channel is encoded by the Shaker (Sh) locus on the X chromosome of D.m. The Shaker complex (ShC) spans over 350 kb in the 16F region of the X chromosome. Drosophila species number about 1,500. Shaker cognate b, isoform K. Gene. mutant for the Shaker (Sh) locus in Drosophila melanogaster were detected originally because they shake their legs vigor-ously under anesthesia (1-3). Either Drosophila PRs fail to increase Shaker expression in response to increased gene dosage or channel function is limited by the supply of an accessory subunit. 1985 Sep; 2 (4):253–271. &�43�����������������������������������������������������������������������������������������;�dd �r#��D����@�3�X�APAq�-�r`�9 �B�C6e' ���A���� Ћ�IȊ'V"8dr �paʃhCЅ���J���Jk�NA��r�9;%�A���r��� ܂P�� rjCP�"t"D4���hӪ� ��B���!u�p��qp�ł:G�O|���ae����I�t�X3���E��4�#�3��Ȏ��A��ê�a�c-��>l#���G�����Fa This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. The Shaker (Sh) gene, when mutated, causes a variety of atypical behaviors in the fruit fly, Drosophila melanogaster. lg�>�jr#�?����m�wn���0D.$�a�3�m8J�1 � ��x,���M�� �u��V �w���z__������{�t��7^�u�_L:KI�� "+Math.floor(new Date().getTime()/3600000); �n�vn�+[� Proc Natl Acad Sci … Geographic Range. Gene #3 1. It can be dissected by means of aneuploids into three main sections: the maternal effect (ME), the viable (V) and the haplolethal (HL) regions.